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Innovation Watch Newsletter 4.11
May 28, 2005

ISSN: 1712-9834


In this issue...


This week's theme is changing the rules... as research points to the possibility of life extension; scientists develop three-stranded DNA; a new kind of city emerges; China settles boundary problems by flexing economic muscle; and a US professor forecasts future Asian ownership of the largest global corporations.

Living longer...

Science News reports that antioxidants have now been proven to increase life span in mice. Researchers at the University of Washington genetically engineered three strains of mice to produce additional catalase antioxidant. In each strain, catalase was directed to a different location in the cell: to the peroxisomes -- the normal cell location; to the cell nucleus; or to the mitochondria. Mice with extra antioxidant in their mitochondria lived about 5 months longer than their counterparts, which had a normal 3-year life span. The long-lived mice not only had an extended life span -- they stayed healthy longer.

Changing the code...

Scientists at the Scripps Research Institute have created a new system that replicates artificial DNA containing three base pairs. While the system is more error prone than replication of the double-stranded DNA that occurs in nature, it is the first time artificial DNA has been replicated with any fidelity. According to Innovations Report, the Institute is still working on improvements.

Flying close to the Sun...

Venus is a harsh place for interplanetary explorers, destroying every probe and lander sent from the Earth. However, New Scientist says a solar-powered aircraft could provide the answer. Since Venus's atmosphere is dense, the plane could fly effortlessly, and indefinitely, using solar panels to power its flight. Staying in the upper atmosphere, where the temperature is a relatively balmy 100 C, it would house the electronics required to control a rover. The ground vehicle would be engineered to withstand more extreme temperatures, reaching 450 C on the planet's surface, 50 kilometers below.

Boomer bust...

Jeremy Siegal -- professor of finance at the Wharton School -- says that when boomers retire and sell their assets, the result may be a market meltdown. Only a massive influx of capital from India, China and other countries will save the situation, he believes. The Pittsburgh Post-Gazette quotes from his new book, The Future for Investors. "By the middle of this century," Siegal says, "I believe the Chinese, Indians and other investors from these young countries will gain majority ownership in most of the large global corporations."

A new kind of city...

The San Francisco Chronicle says the world has created a new kind of metropolis -- ephemeral cities -- and San Francisco is one of them. Writer Joel Kotkin describes these places as, "No longer populated mainly by middle class families and a diverse set of industries," but instead "...dominated by a wealthy elite, part-time sojourners, hordes of tourists and those that serve them." Business, he says, has largely moved to suburbia. Families, too, are leaving. San Francisco has the lowest percentage of children in the United States.

China's borders...

Business opportunities may overcome the political differences between Taiwan and China, Business Week says. Taiwanese companies have invested $100 billion in the mainland in the past two decades, and China buys three-quarters of the island's exports. Pro-business interests dominated in the last Taiwanese election, and Taiwanese executives are becoming more openly critical of the Democratic Progressive Party that favors independence. "For the true picture of what's happening in this controversy," the magazine says, "forget the rhetoric from both sides and just follow the money."

The BBC reports that China and India have signed an historic agreement to resolve the dispute over their 3,550 kilometer Himalayan border. Both have relinquished claims to land they previously argued was occupied by the other. They have jointly set a target for $30 billion in additional annual trade by 2010, and may look to establish closer ties in science and technology. The article quotes Chinese premier Wen Jiabao, "If India and China cooperate in the IT industry, we will be able to lead the world... and it will signify the coming of the Asian century of the IT industry."

Scratch and sniff...

Allergies have increased almost five percent per decade in the last 25 years, according to British researchers. They based their findings on tissue samples collected since the 1970s. While there has been much anecdotal evidence that allergic reactions are increasing, no-one yet knows why.

Future evolution...

In a futuristic feature article, MSNBC speculates on the genetic fate of humankind. Diversity could be reduced as our gene pool continues to converge, some scientists say, so we increasingly become an "animal monoculture." Alternatively, epidemics and environmental catastrophes could create new species. Genetic engineering and enhancement could produce a "new kind of human." And Homo sapiens could merge in the future with intelligent machines. We might even travel to other planets, the writer says, growing "new branches on our evolutionary family tree."

David Forrest


we welcome your comments and feedback at mail@innovationwatch.com


SCIENCE

Monitoring Program Finds Serious, Unreported Adverse Drug Reactions - [Science Daily] A monitoring program developed by a Northwestern University researcher has successfully identified a large number of previously unknown, serious and often-fatal drug reactions associated with 15 commonly used drugs, including Plavix®, thalidomide and drug-coated cardiac stents.

Long Live the Mammals: Antioxidant Redirection Extends Mouse Life Span - [Science News] Cranking up the amount of antioxidants naturally produced in the body and directing those molecules to where they're needed can dramatically slow the aging process, according to a new study in mice. The finding adds credence to the controversial idea that antioxidants can extend life in people and other mammals.

Universe Reveals Its Dark Side - [Physics World] Evidence for dark matter is growing, and so are our chances of directly detecting it.

Jefferson Scientists Create Plant Factories Churning Out Antibodies Against Tumor Cells - [Science Daily] Scientists at Jefferson Medical College are using tobacco plants to produce monoclonal antibodies -- tiny guided protein missiles -- that can target and hunt down cancer cells. The plants promise to provide a cheaper, faster method of producing anticancer antibodies, raising hopes that the technology can one day be used in humans.

Noisy Pictures Tell a Story of 'Entangled' Atoms, Physicists Find - [Science Daily] Patterns of noise -- normally considered flaws -- in images of an ultracold cloud of potassium provide the first-ever visual evidence of correlated ultracold atoms, a potentially useful tool for many applications, according to physicists at JILA, a joint institute of the National Institute of Standards and Technology (NIST) and the University of Colorado at Boulder.

Testing Blood to Track History - [Wired] The Genographic Project will collect 100,000 blood samples from indigenous populations and analyze their DNA. Through this project, researchers hope to answer questions about where the aborigines of Australia came from, or whether it's true that Alexander the Great fathered the blue-eyed blondes who have been in Afghanistan for more than 2,000 years.

DNA With Three Base Pairs - A Step Towards Expanding the Genetic Code - [Innovations Report] Scientists at The Scripps Research Institute in La Jolla, California reported progress toward the creation of a system for replicating a modified form of DNA containing an unnatural base pair.


TECHNOLOGY

To Conquer Venus, Try a Plane with a Brain - [New Scientist] Space scientists in the US believe a solar-powered aircraft could explore the atmosphere of the second rock from the sun, and carry a flying "brain" to control a toughened rover on the ground.

Put a Chip in It! - [Inc.] Someday, anthropologists will cluck over the fact that even into the early 21st century Americans had to wave at waiters and bartenders if they wanted a refill on their beer. That's because a research laboratory run by Mitsubishi has developed the world's first "smart" beer mug. It's equipped with a dishwasher-safe microchip in the bottom that senses when the glass is down to dregs and sends a distress signal.

Word's Open-Source Competition - [Wired] The latest version of the free OpenOffice suite promises to be a strong competitor to Microsoft Office. It's still in beta, but it's already a good alternative -- and you can't argue with the price.

Wal-Mart Tests Robots for Blind Shoppers - [CIO Insight] Wal-Mart started quietly testing a university-created robot designed to help visually impaired consumers navigate store aisles and find their desired products. The robot -- named RG, for Robotic Guide -- is the creation of Vladimir Kulyukin, an assistant professor of computer science at Utah State University and the director of the university's Computer Science Assistive Technology Laboratory.

Deciphering DNA, Top Speed - [Technology Review] The sequencing of the human genome is one of biotech’s greatest technical achievements to date. But some biomedical researchers argue that they won’t truly understand how genes contribute to health and disease— and so won’t be able to turn genomic knowledge into new cures and treatments—until they can compare, letter by letter, the DNA sequences of thousands of sick and healthy people.

Using Lasers to Play Old-Fashioned Records - [ABC News] With an estimated 30 billion platters of vinyl still in the hands of audiophiles, collectors and die-hard music fans today, old-fashioned records haven't exactly faded away. And now a small Japanese company called ELP believes it can bring old school albums a new spin at life -- thanks in part, to CD technology.

NASA Receives Proposal for Next Spaceship - [MSNBC] The future of human space transportation, not only into Earth orbit, but also back to the moon and on to Mars, kick-started this week as NASA received contractor proposals for the Crew Exploration Vehicle.


BUSINESS AND ECONOMY

The Supply Chain of the 21st Century - [Supply & Demand Chain] There is great value in harnessing the power of supply chain ecosystems to drive growth and efficiency in a business. Applying ecosystem principles helps businesses create and master this "chain of chains" that envelops the multi-enterprise scope of the company's suppliers and customers to function as one synchronized unit.

As Boomers Retire, a Debate: Will Stock Prices Get Crushed? - [Post-Gazette] Jeremy Siegel, the Wharton School finance professor, is warning that a flood of boomer retirees with trillions of dollars of assets to sell over the next 20 to 40 years threatens to crush stock and bond prices. He says it will take a massive investment in US stocks by people in India, China and other developing countries to prevent a market meltdown.

Start-Up Composes a 'Music Genome' - [Boston Globe] Savage Beast Technologies Inc., a five-year-old software start-up, is busy building a ''music genome" to identify the world's recorded music according to vocal, lyrical, melodic, harmonic, and instrumental attributes. The results are fed into a massive database to spit out recommendations for music-loving shoppers at Best Buy, Borders, AOL, and other retailers that license Savage Beast technology.

Today's Grads Do Work Hard, On Their Own Terms - [Seattle Post-Intelligencer] Young people today can and do work very hard. It's just that it's more on their own terms. They want great jobs in great companies. They want jobs where they can make an impact, where their skills and knowledge will be put to the test in organizations that are driven by leading-edge thinking.

Ads That Know What You Want - [Wired] Targeted marketing is nothing new in the online world, as anyone who's ever received personalized book recommendations from Amazon.com can attest. However, by recording peoples' movements over networks of web properties rather than just individual sites, some marketers are betting that they will be able to improve response rates to online ad campaigns dramatically.

Check into the 'Hotel of Tomorrow' - [USA Today] Scenarios for the hotel room of 2025 that emerged at brainstorming sessions of five dozen high-level lodging designers, suppliers and others from inside and outside the industry.

'Homeshoring' Means That Call Center Might Be in Someone's Bedroom - [Seattle Post-Intelligencer] The move to home-based agents, working from bedrooms and kitchen tables across the country, started as a trickle in the late 1990s. But it is picking up speed as a low-cost alternative to traditional call centers.


SOCIETY

Language: Empires of the Word by Nicholas Ostler - [Sunday Times] The scope of Ostler’s book is almost preposterously ambitious: the “language history of the world” is, after all, pretty much synonymous with the human habitation of the world, and, although Ostler approaches his grand theme from the point of view of an expert in languages and linguistics, he doesn’t stint his duties as a historian of military, social, religious and even agricultural history.

India's Poverty: Help the Poor Help Themselves - [International Herald Tribune] While India's growth makes it an economic and political player to watch in the next decades, the country remains desperately poor. Almost a quarter of India's 1.1 billion people live on less than $1 a day; 700 million more live on less than $2 a day. Can India ever overcome its huge poverty problem? It depends on what strategy the country takes.

The Ephemeral City - [San Francisco Chronicle] San Francisco today represents the ultimate expression of a new kind of urban area -- the ephemeral city. This urban form, dominated by the nomadic rich, the restless young and those living off them, has emerged across the advanced industrial world, but perhaps nowhere more clearly and arguably nowhere more successfully than in the city by the bay.

Flat World Fatigue: Globalization Breeds Interminable Work Day - [Seattle Times] Even the most unapologetic globalization proponents nevertheless acknowledge that offshoring has resulted in longer, stranger hours for white-collar workers in the United States. Some business experts worry that the trend could result in massive burnout if offshoring isn't properly managed.

State Bill to Limit RFID - [Wired] While civil libertarians battle the federal government's decision to embed RFID chips in new U.S. passports, a California bill is moving swiftly through the state legislature that would make it illegal for state agencies and other bodies to use the technology in state identification documents.

Goal: Educate World's Kids With $100 PCs - [Christian Science Monitor] A cheap laptop in the hands of every child in the developing world. It's the kind of dream reminiscent of the dotcom fervor of the 1990s - and a personal goal of Nicholas Negroponte since the 1980s. But only recently has the funding been secured to move forward on his goal: a portable computer that can survive excessive dust and 130-degree days, recharge itself in villages with no power, and hook up to the Internet when the nearest server is hundreds of miles away. The cost? No more than $100.

State to Ban Bosses Snooping on Emails - [The Australian] Employers will face criminal charges if they illegally spy on workers' emails under legislation introduced in NSW parliament. NSW is the first state to move on "tech snooping", with Victoria and South Australia understood to be considering similar legislation.


GLOBAL POLITICS

China Bristles at Textile Trade Backlash - [Washington Post] Chinese officials argue that their country is the scapegoat for the inevitable demise of American manufacturing: If American closets were not full of Chinese-made clothes, they would instead be occupied by goods from some other developing country.

What If the British Vote No? - [Foreign Affairs] If ratified, the new EU constitution will change the way the union works. It cannot take effect unless approved by all 25 members, but in only one country -- the United Kingdom -- do polls show that a majority oppose the document. Still, a rejection there would throw Europe into a constitutional crisis. And it could ultimately harm transatlantic relations as well.

China and India Sign Border Deal - [BBC] India and China have signed an agreement in Delhi aimed at resolving a long-running dispute over their Himalayan border.

Safeguarding Russian Freedoms - [The Globalist] Russia’s President Vladimir Putin has been strongly criticized for a rollback of economic and political rights in his country. Where does Mr. Putin see Russia heading in the future -- both economically and politically? We present his key points in this Globalist Document based on his Annual Address to the Federal Assembly.

China Walks Nationalist Tightrope - [BBC] Beijing has moved to stem anti-Japan rallies after having been happy to let them rage through several Chinese cities last month. It has shut down nationalist websites, detained dissidents and sent out text messages warning against illegal demonstrations.

A Tough Road in Curbing Spread of Nuclear Arms - [Christian Science Monitor] As representatives of 189 nations gather in New York to try to stop the spread of nuclear weapons, the world's nuclear haves and have nots are ratcheting up threats accompanying a month-long review of the Nuclear Non-Proliferation Treaty (NPT).

China's New Taiwan Tack - [Business Week] What if the long struggle to preserve Taiwan's tenuous independence from China were scuttled not by a military confrontation but by a thundering herd of Taiwanese businessmen tripping over each other to pump more billions into mainland plants for making chips and liquid-crystal displays? It's not a far-fetched worry. Taiwanese companies have invested some $100 billion in the mainland over the past two decades, and these days China buys three-quarters of Taiwan's exports.


ENVIRONMENT

Allergies On Rise, 25-year Study Shows - [CBC] For decades, people have suspected seasonal allergies are becoming more common. Now some tissue samples confirm the 25-year trend to more sneezes and itchy eyes.

Fishing Gear Awarded for Saving Marine Life - [MSNBC] Three designs for fishing gear that doesn't trap sea turtles, birds and other so-called "bycatch" took the top prizes in a competition held by the World Wildlife Fund and several partners.

Ethanol Grows as Gas Alternative - [Wired] Workers are clearing Iowa fields, hoping that if they build it, cars will come. The "it" is a processing plant that turns corn into ethanol, a fuel that is increasingly replacing gasoline today and may help to power the fuel-cell vehicles of tomorrow.

Peak Oil Slowly Seeping into National Conciousness - [EV World] Until recently, peak-oil analysts got about as much respect from the energy establishment as do perpetual-motion enthusiasts. But now, with oil prices headed for uncharted territory and even Saudi Arabia seemingly unable to boost production to higher levels, the peak oil idea -- which says that world oil production will go into irreversible decline sometime in the the next decade or two -- is quickly morphing into conventional wisdom.

Ocean Tells the Story: Earth is Heating Up - [BBC] New temperature readings from the deep ocean trace a clear warming trend that seems impossible to turn around any time soon, scientists reported, promising a steadily warming world and raising the odds of a catastrophic sudden change marked by rising seas and melting icecaps.

NASA's Exploration Focus Blamed for Earth Science Cuts - [Space News] NASA merged its Earth science and space science programs into a single organization, the Science Mission Directorate, in 2004 and no longer maintains separate budgets for the two activities. But according to a House Science Committee analysis of NASA's budget request, of the $5.47 billion included for the Science Mission Directorate, only $1.36 billion would be spent on Earth science activities, a drop of 8 percent below the 2005 level and 12 percent less than the 2004 level.

Environmentalists Crank Up Heat On Utilities - [ENN] Turning up the heat on publicly traded power companies that are contributing to global warming, the National Environmental Trust recently compiled a list of the industry's top 50 greenhouse gas producers.


THE FUTURE

Human Evolution at the Crossroads - [MSNBC] Scientists are fond of running the evolutionary clock backward, using DNA analysis and the fossil record to figure out when our ancestors stood erect and split off from the rest of the primate evolutionary tree. But the clock is running forward as well. So where are humans headed?


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